Callist Tindimugaya was educated at Makerere University, Kampala (Uganda), where he obtained a BSc honours degree in Geology and Chemistry (1987 to 1990). He later joined the International Institute for Infrastructural, Hydraulic and Environmental Engineering (IHE) at Delft, obtaining an MSc in Hydrology and Water Resources with specialization in groundwater hydrology (1998 to 2000). Callist joined the Management College of Southern Africa, Durban (South Africa) in 2003 successfully completing an MBA in 2008 in addition to attending University College London, where he obtained a PhD in Groundwater Resources Management in 2008.
Callist started his professional career in 1990 as hydrogeologist in the Ministry of Natural Resources (Uganda) and rose to the position of Principal Hydrogeologist and Head of the Groundwater Section in 1999, responsible for all groundwater management activities in Uganda. From 2007, he was elevated to the position of Commissioner for Water Resources Planning and Regulation in the Ministry of Water and Environment (Uganda), responsible for planning and regulating the use of the water resources of Uganda. Callist has been key in ensuring the water resources of Uganda are developed and managed in an integrated and sustainable manner. One of his major projects is the Groundwater Mapping Programme for Uganda funded by the European Union (a 2.2 million Euros project involving the preparation of national and district groundwater maps for guiding planning of groundwater development activities in 44 districts). Callist has also worked on various groundwater development and management projects in over 10 countries in Africa as an Isotope Hydrology Expert for the International Atomic Energy Agency (IAEA).
Callist is a Regional Coordinator for the Nile Integrated Water Resources Management Network, Chairman, Uganda Groundwater Professionals Association/National Chapter IAH, Member of the IAH Burdon Network, Steering Committee Member of the African Groundwater Network (AGWNET), and Chairman of the UNESCO National Committee for the International Hydrological Programme in Uganda. Callist has supervised more than a dozen postgraduate students at Makerere University and is involved in the facilitation of various courses on groundwater and integrated water resources management.